Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection

WS Lee; HX Tan; A Reynaldi; R Esterbauer; M Koutsakos; J Nguyen; T Amarasena; HE Kent; A Aggarwal; SG Turville; G Taiaroa; P Kinsella; KC Liew; T Tran; DA Williamson; D Cromer; MP Davenport; SJ Kent; JA Juno; DS Khoury; AK Wheatley

Journal article

Durable reprogramming of neutralizing antibody responses following Omicron breakthrough infection

WS Lee, HX Tan, A Reynaldi, R Esterbauer, M Koutsakos, J Nguyen, T Amarasena, HE Kent, A Aggarwal, SG Turville, G Taiaroa, P Kinsella, KC Liew, T Tran, DA Williamson, D Cromer, MP Davenport, SJ Kent, JA Juno, DS Khoury Show all

Science Advances | Published : 2023

DOI: 10.1126/sciadv.adg5301

Open access

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection of vaccinated individuals is increasingly common with the circulation of highly immune evasive and transmissible Omicron variants. Here, we report the dynamics and durability of recalled spike-specific humoral immunity following Omicron BA.1 or BA.2 breakthrough infection, with longitudinal sampling up to 8 months after infection. Both BA.1 and BA.2 infections robustly boosted neutralization activity against the infecting strain while expanding breadth against BA.4, although neutralization activity was substantially reduced for the more recent XBB and BQ.1.1 strains. Cross-reactive memory B cells against both..

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University of Melbourne Researchers

Wen Shi Lee Author

Hyon Xhi Tan Author

Robyn Esterbauer Author

Marios Koutsakos Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

& nbsp;This work was supported by Australian National Health and Medical Research Council grants 1149990, 1162760, and 2004398; Australian Medical Research Future Fund grants 2005544 and 2013870; the Victorian government; Australian National Health and Medical Research Council Investigator or Fellowship grants (H.-X.T., M.K., D.A.W., M.P.D., S.J.K., J.A.J., and A.K.W.); and Melbourne Postdoctoral Fellowship (W.S.L.).& nbsp;& nbsp;